Receptor mediated gonadotropin action in gonadal tissues: Relationship between blood cholesterol levels and gonadotropin stimulated steroidogenesis in isolated rat leydig and luteal cells
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Receptor mediated gonadotropin action in gonadal tissues: relationship between blood cholesterol levels and gonadotropin stimulated steroidogenesis in isolated rat Leydig and luteal cells.
The present studies were performed to evaluate the role of steroid precursors and plasma lipoproteins in gonadal tissue steroidogenesis. Leydig cell suspension isolated from rat testes responded to hCG. Bt2cAMP, 8 Br-cAMP and cholera toxin with an increase in testosterone response. Administration of 4-aminopyrazolo[3,4-d]pyrimidine (4-APP) reduced the plasma cholesterol and testosterone levels ...
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F : Ovarian cells isolated from 26 day old rats responded to hCG IO rig/ml) and cholera enterotoxin (100 rig/ml) in vitro with a forty-five to -fifty-fold increase in progesterone production. Both cholera enterotoxin and hCG-stimulated progesterone response was accompanied by a lag period. The duration of the lag period in the production of the progesterone depended on the concentration ot gona...
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Testicular tumors are generally characterized by a loss of responsiveness to gonadotropins. The M5480 Leydig cell tumor is unusual, if not unique, in that it responds to human choriogonadotropin and to lutropin via increased steroidogenesis. This report describes the identification of two variants of the original M5480 tumor that have altered steroid output both in the basal state and in respon...
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Incubation of luteal cells with human, horse and rat sera, but not bovine sera resulted in enhanced basal and hCG-stimulated progesterone accumulation. The stimulatory effect of human or rat sera on basal, hCG- or 8 Br-cyclic AMP-induced progesterone synthesis in luteal cells was evident within 15-30 min after incubation, reaching a maximum after 3-4 h. The stimulatory effects of hCG and/or ser...
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The steroidogenic lesion produced in Leydig cells by gonadotropin stimulation has been attributed to an inhibitory effect of estrogen on 17a-hydroxylase and 17,20-desmolase activity, with impaired conversion of progesterone to androgens. In animals treated with doses of human chorionic gonadotropin (hCG) or gonadotropin-releasing hormone (GnRH) that caused the decrease in desmolase activity, ad...
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ژورنال
عنوان ژورنال: Journal of Steroid Biochemistry
سال: 1982
ISSN: 0022-4731
DOI: 10.1016/0022-4731(82)90165-0